Testing of PLK1 Signaling in Lupus

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2017-10-12

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Our goal is to identify novel therapeutic targets of Lupus and test their potential. Polo-Like Kinase 1 (PLK1) is one of the molecules that we have identified and shown to be hyper-activated in immune cells of lupus mice, we want to test if the blockade of PLK1 could ameliorate lupus, and find out the underlying molecular and cellular mechanism.

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