Bioimaging of Flow Dynamics in BTB
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Gloriosa superba is a well-known source of the bioactive colchicine. It is one of the primary sources of treatment for gout and under drug development for cancer as well as cardiovascular diseases. The balloon type bubble bioreactor (BTBR) has been successfully used for the production of biopharmaceuticals. The biomanufacturing of colchicine can be increased by understanding the flow dynamics, mixing intensity inside the BTBR. The preliminary results illustrate the homogenous and heterogeneous flow patterns, the direction of flow inside the reactor at low and high gas injection rates. We will present the mean bubble diameter, the maximum and the minimum vorticity, density of the fluid, viscosity, and surface tension bioimaging as well as quantitative data, which could provide better understanding of the fluid dynamics for the biomanufacturing of biorhizome for therapeutic colchicine production.