Show simple item record

dc.contributor.authorRodgers, Shaefali P.
dc.contributor.authorTrevino, Melissa
dc.contributor.authorZawaski, Janice A.
dc.contributor.authorGaber, M. Waleed
dc.contributor.authorLeasure, J. Leigh
dc.date.accessioned2018-02-21T22:26:46Z
dc.date.available2018-02-21T22:26:46Z
dc.date.issued2013-04
dc.identifier10.1155/2013/698528
dc.identifier.citationCopyright 2013 Neural Plasticity. Recommended citation: Rodgers, Shaefali P., Melisa Trevino, Janice A. Zawaski, M. Waleed Gaber, and J. Leigh Leasure. “Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy.” Neural Plasticity 2013 (2013): 1-9. doi: 10.1155/2013/698528. URL: https://www.hindawi.com/journals/np/2013/698528/abs/. Reproduced in accordance with licensing terms and with the author’s permission.
dc.identifier.urihttp://hdl.handle.net/10657/2270
dc.description.abstractBrain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive “late” effects that may take years to fully manifest. These late effects likely derive from a long-term decrement in cell proliferation, combined with a neural environment that is hostile to plasticity, both of which are induced by RT. Long-term suppression of cell proliferation deprives the brain of the raw materials needed for optimum cognitive performance (such as new neurons in the hippocampus and new glia in frontal cortex), while chronic inflammation and dearth of trophic substances (such as growth hormone) limit neuroplastic potential in existing circuitry. Potential treatments for cognitive late effects should address both of these conditions. Exercise represents one such potential treatment, since it has the capacity to enhance cell proliferation, as well as to promote a neural milieu permissive for plasticity. Here, we review the evidence that cognitive late effects can be traced to RT-induced suppression of cell proliferation and hostile environmental conditions, as well as emerging evidence that exercise may be effective as an independent or adjuvant therapy.
dc.language.isoen_US
dc.publisherNeural Plasticity
dc.titleNeurogenesis, exercise, and cognitive late effects of pediatric radiotherapy
dc.typeArticle


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record