A clinical study using a computer to determine amikacin dosage regimens

Date

1977

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Abstract

Amikacin (BB-K8) is a new aminoglycoside antibiotic with an antimicrobial spectrum like that of gentamicin and pharmacokinetic characteristics like that of kanamycin. Due to amikacin's resistance to some enzymes which inactivate other aminoglycosides, amikacin is used against susceptible bacteria which are resistant to other aminoglycosides. The toxicity of amikacin is not unlike that of other aminoglycosides. The potential for ototoxicity and nephrotoxicity requires careful monitoring of patients receiving amikacin. The purpose of the present study was to evaluate the feasibility of using a computer to determine amikacin dosage regimens. To accomplish this, computer predicted amikacin serum levels were compared with clinical results. Computer predictions were based upon the patient's serum creatinine concentration, body weight, age, and sex. Two computer predictions were made for each patient. One computer prediction was based upon the creatinine clearance determined by the Siersbaek-Nielsen equation, while the other prediction was based upon the creatinine clearance determined by the computer fit model derived from clinical results. [...]

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Keywords

Amikacin

Citation