Strong Base Mediated Intramolecular Cyclopropanation
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The strong base lithium tetramethylpiperidide (LiTMP) was used to introduce a cyclopropane moiety in a minimally functionalized molecule. This new method uses a triflate leaving group to form a carbene intermediate that reacts in a statistical fashion with any adjacent hydrogens to form the cyclopropane structure. Further experimenting with the reaction conditions for functional group tolerance will allow for more complex molecules to be modified in the future. Developing new methods to synthesize cyclopropanes would allow for late-stage modification of existing drugs or natural products to further medicinal research.