Now showing items 1-6 of 6
Association of GRK3 with stress resilience and stress susceptibility: Behavioral and pharmacological evidence
On exposure to stress, persistent stimulation of alpha2A-adrenoceptors (α2A-AR) and corticotrophin-releasing factor 1 receptors (CRF1-R) increase the receptor signaling in locus coeruleus (LC) and amygdala (two critical ...
Effect of Selective Up regulation of Prostacyclin Synthesis On Its Signaling And Vascular Protection
Prostacyclin (PGI2) is a very important endogenous vascular protector. It provides vascular protection through actions like vasodilatation, platelet aggregation and vascular smooth muscle cell proliferation inhibition and ...
OXIDATIVE STRESS AND RENAL AT1R FUNCTION DURING HYPERTENSION
Angiotensin (Ang) II via renal Ang II type 1 receptors (AT1R) modulates proximal tubular Na/K-ATPase such that, low concentrations of Ang II stimulates Na/K-ATPase whereas at high concentrations the stimulatory effect is ...
Role of Vascular Oxidative Stress in Hypertension
Hypertension affects 1 in 3 adult Americans and is a primary risk factor for cardiovascular diseases. Better understanding of hypertension pathogenesis is important for development of effective therapeutic agents. An ...
Role of Angiotensin II Type 2 Receptor in Blood Pressure Regulation in Obese rats
Renin angiotensin system (RAS) consists of enzymes, hormones, proteins and peptides. Angiotensin II (Ang II) is an important peptide of RAS. Ang II acts via AT1 receptor (AT1R) and AT2 receptor (AT2R). While AT1R is known ...
ROLE OF AGE-ASSOCIATED OXIDATIVE STRESS IN ALTERED RENAL D1 AND AT1 RECEPTOR FUNCTIONS AND HYPERTENSION
Blood pressure (BP) and oxidative stress increase with aging. Renal dopamine D1 (D1R) and angiotensin AT1 (AT1R) receptors by maintaining sodium homeostasis regulate blood pressure. Impaired D1R and exaggerated AT1R functions ...