Now showing items 1-2 of 2

    • Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease 

      Takahashi, Kou; Kong, Qiongman; Lin, Yuchen; Stouffer, Nathan; Schulte, Delanie A.; Lai, Liching; Liu, Qibing; Chang, Ling-Chu; Dominguez, Sky; Xing, Xuechao; Cuny, Gregory D.; Hodgetts, Kevin J.; Glicksman, Marcie A.; Lin, Chien-Liang G. (Journal of Experimental Medicine, 2015-02)
      Glutamatergic systems play a critical role in cognitive functions and are known to be defective in Alzheimer’s disease (AD) patients. Previous literature has indicated that glial glutamate transporter EAAT2 plays an essential ...
    • Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection 

      Kong, Qiongman; Chang, Ling-Chu; Takahashi, Kou; Liu, Qibing; Schulte, Delanie A.; Lai, Liching; Ibabao, Brian; Lin, Yuchen; Stiufferm Nathan; Mukhopadhyay, Chitra D.; Xing, Xuechao; Seyb, Kathleen I.; Cuny, Gregory D.; Glicksman, Marcie A.; Lin, Chien-Liang G. (Journal of Clinical Investigation, 2014-02)
      Glial glutamate transporter EAAT2 plays a major role in glutamate clearance in synaptic clefts. Several lines of evidence indicate that strategies designed to increase EAAT2 expression have potential for preventing ...