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    • Identification of RIP1 kinase as a specific cellular target of necrostatins 

      Degterev, Alexei; Hitomi, Junichi; Germscheid, Megan; Ch'en, Irene L.; Korkina, Olga; Teng, Xin; Abbott, Derek; Cuny, Gregory D.; Yuan, Chengye; Wagner, Gerhard; Hedrick, Stephen M.; Gerber, Scott A.; Lugovskoy, Alexey; Yuan, Junying (Nature Chemical Biology, 2017-05)
      Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented. ...